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Science 22 January 1971:
Vol. 171. no. 3968, pp. 300 - 303
DOI: 10.1126/science.171.3968.300
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Articles

Urinary Adenosine 3',5'-Monophosphate in the Switch Process from Depression to Mania

Michael I. Paul 1, Hinrich Cramer 2, and William E. Bunney Jr. 3

1 Neuropsychiatric Institute, Center for the Health Sciences, University of California, Los Angeles 90024
2 Laboratory of Chemical Pharmacolog, National Heart and Lung Institute, Bethesca, Maryland 20014
3 Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014

Marked elevations of urinary adenosine 3',5'-monophosphate occurred on the day of rapid switch from a depressed into a manic state in patients with manic-depressive illness. It is suggested that this increase might serve a trigger function for the process by which catecholamines are elevated during the manic phase of the illness.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The "Switch Process" in Manic-Depressive Illness: II. Relationship to Catecholamines, REM Sleep, and Drugs.
W. E. Bunney Jr., F. K. Goodwin, D. L. Murphy, K. M. House, and E. K. Gordon (1972)
Arch Gen Psychiatry 27, 304-309
   Abstract »    PDF »
Studies on the Mechanism of Hormone Action.
E. W. Sutherland (1972)
Science 177, 401-408
   PDF »
Adenosine 3',5'-Monophosphate and Mania.
H. Meltzer (1971)
JAMA 216, 1856-1857
   Abstract »    PDF »


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