Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 15 January 1971:
Vol. 171. no. 3967, pp. 208 - 210
DOI: 10.1126/science.171.3967.208
Prev | Table of Contents | Next

Articles

Supraoptic Neurosecretory Cells: Adrenergic and Cholinergic Sensitivity

Jeffery L. Barker 1, John W. Crayton 1, and Roger A. Nicoll 1

1 Laboratory of Neuropharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032

Adrenergic and cholinergic agonists and antagonists were applied microelectrophoretically to over 700 neurons in the cat supraoptic nucleus, 20 percent of which were antidromically identified as neurosecretory cells. Norepinephrine uniformly depressed all sensitive cells. Acetylcholine caused both muscarinic depression and nicotinic excitation which were antagonized by atropine and dihydro-beta-erythroidine, respectively. These results support the hypothesis that norepinephrine and acetylcholine are directly involved in controlling the release of antidiuretic hormone.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Supraoptic nucleus of the Brattleboro rat has an altered afferent noradrenergic input.
J Scholer and J. Sladek Jr (1981)
Science 214, 347-349
   Abstract »    PDF »
Supraoptic Neurosecretory Cells: Adrenergic and Cholinergic Sensitivity.
J. L. Barker, J. W. Crayton, and R. A. Nicoll (1971)
Science 171, 208-210
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)