Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 15 January 1971:
Vol. 171. no. 3967, pp. 199 - 201
DOI: 10.1126/science.171.3967.199
Prev | Table of Contents | Next

Articles

Expression of Allelic Immunoglobulin in Homozygous Rabbits Injected with RNA Extract

Clara Bell 1 and Sheldon Dray 1

1 Department of Microbiology, University of Illinois at the Medical Center, Chicago 60680

Ribonucleic acid extracts obtained from lymph nodes of immunized rabbits homozygous for the b4or b5allele of light chain immunoglobulin allotypes were injected intravenously into nonimmunized rabbits homozygous for the alternate allele. Approximately 30 percent of the plaque-forming cells in the spleen yielded plaques with immunoglobulin M antibody possessing the allotype of the RNA donor. The allotype of the RNA donor was also found in the IgG immunoglobulin of lymphoid cell lysates as well as in the IgG isolated from the serum. These results suggest that the injected RNA has an informational role in the in vivo synthesis of immunoglobulins by host lymphoid cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Rabbit Immunoglobulin Allotypes: Complexities of Their Genetics, Expression, Structural Basis, and Evolution.
R. G. Mage, G. O. Young-Cooper, J. Rejnek, A. A. Ansari, C. B. Alexander, E. Appella, M. Carta-Sorcini, S. Landucci-Tosi, and R. M. Tosi (1977)
Cold Spring Harb Symp Quant Biol 41, 677-686
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)