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Science 15 January 1971:
Vol. 171. no. 3967, pp. 196 - 197
DOI: 10.1126/science.171.3967.196
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Articles

Factor VIII Detection by Hemagglutination Inhibition: Hemophilia A and von Willebrand's Disease

D. P. Stites 1, E. J. Hershgold 2, J. D. Perlman 3, and H. H. Fudenberg 3

1 Department of Medicine, Section on Hematology and Immunology, University of California School of Medicine, San Francisco 94122
2 Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, California 94305
3 Department of Medicine, Section on Hematology and Immunology, University of California School of Medicine, San Francisco

Factor VIII activity was detected immunologically in both the serums and plasmas of 14 normal individuals and 14 patients with hemophilia A. A hemagglutination-inhibition test with rabbit antibody to highly purified (10,000-fold) factor VIII from humans was used. Serums and plasmas from eight patients with von Willebrand's disease showed little or no factor VIII activity in this test, an indication that the test may serve as a specific assay for differentiation between von Willebrand's disease and hemophilia A.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Antihemophilic Factor (Factor VIII).
O. D. RATNOFF (1978)
Ann Intern Med 88, 403-409
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The Laboratory Diagnosis of the Carrier State for Classic Hemophilia.
O. D. RATNOFF and P. K. JONES (1977)
Ann Intern Med 86, 521-528
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Carbohydrate deficiency of the factor VIII/von Willebrand factor Protein in von Willebrand's disease variants.
H. Gralnick, B. Coller, and Y Sultan (1976)
Science 192, 56-59
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Von Willebrand Factor: Dissociation from Antihemophilic Factor Procoagulant Activity.
H. J. Weiss and L. W. Hoyer (1973)
Science 182, 1149-1151
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The Genetics of Hereditary Disorders of Blood Coagulation: Functional and immunological studies provide evidence for the heterogeneity of many familial clotting disorders.
O. D. Ratnoff and B. Bennett (1973)
Science 179, 1291-1298
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Surgery in von Willebrand's Disease.
S. Adelman, R. W. Monto, and J. L. Ponka (1972)
Arch Surg 105, 204-208
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