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Science 15 January 1971:
Vol. 171. no. 3967, pp. 194 - 196
DOI: 10.1126/science.171.3967.194
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Articles

Cerebellar Hypoplasia in Neonatal Rats Caused by Lymphocytic Choriomeningitis Virus

Andrew A. Monjan 1, Donald H. Gilden 1, Gerald A. Cole 1, and Neal Nathanson 1

1 Department of Epidemiology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205

Lymphocytic choriomeningitis virus, strain E-350, when inoculated intracerebrally in rats 1 to 7 days old, produces an acute destructive infection of the cerebellar cortex resulting in permanent cerebellar hypoplasia and ataxia. Several other arenoviruses may produce a similar lesion in neonatal rodents.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Critical Role for Glial Cells in the Propagation and Spread of Lymphocytic Choriomeningitis Virus in the Developing Rat Brain.
D. J. Bonthius, J. Mahoney, M. J. Buchmeier, B. Karacay, and D. Taggard (2002)
J. Virol. 76, 6618-6635
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)