Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 8 January 1971:
Vol. 171. no. 3966, pp. 79 - 82
DOI: 10.1126/science.171.3966.79
Prev | Table of Contents | Next

Articles

Vitamin D: A Cholecalciferol Metabolite Highly Active in Promoting Intestinal Calcium Transport

James F. Myrtle 1 and Anthony W. Norman 1

1 Department of Biochemistry, University of California, Riverside 92502

A major polar metabolite of cholecalciferol (vitamin D3) obtained from chick intestines is over four times as effective as cholecalciferol and over two times as effective as 25-hydroxycholecalciferol in stimulating intestinal calcium transport 24 hours after administration. Following a considerable lag, cholecalciferol and its 25-hydroxy derivative produce a maximum stimulation of the transport response at 24 to 48 hours. The polar intestinal metabolite greatly shortens this lag, stimulating maximum calcium transport by 9 hours. At 9 hours this metabolite is at least 13 times as active as the parent cholecalciferol and as such is a likely candidate for the biologically active form of cholecalciferol in the intestine.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
1,25-Dihydroxyvitamin D in biological fluids: a simplified and sensitive assay.
J. Eisman, A. Hamstra, B. Kream, and H. DeLuca (1976)
Science 193, 1021-1023
   Abstract »    PDF »
Vitamin D: 3-deoxy-lalpha-hydroxyvitamin D3, biologically active analog of lalpha-dihydroxyvitamin D3.
A. Norman, M. Mitra, W. Okamura, and R. Wing (1975)
Science 188, 1013-1015
   Abstract »    PDF »
Vitamin D Intoxication in an Anephric Child.
S. J. COUNTS, D. J. BAYLINK, F.-H. SHEN, D. J. SHERRARD, and R. O. HICKMAN (1975)
Ann Intern Med 82, 196-200
   Abstract »    PDF »
1agr-Hydroxy Derivative of Vitamin D3: A Highly Potent Analog of 1agr,25-Dihydroxyvitamin D3.
M. F. Holick, E J. Semmler, H. K. Schnoes, and H. F. Deluca (1973)
Science 180, 190-191
   Abstract »    PDF »
1,25-Dihydroxycholecalciferol: Identification of the Proposed Active Form of Vitamin D3 in the Intestine.
A. W. Norman, J. F. Myrtle, R. J. Miogett, H. G. Nowicki, V. Williams, and G. Popjaak (1971)
Science 173, 51-54
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)