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Science 8 January 1971:
Vol. 171. no. 3966, pp. 79 - 82
DOI: 10.1126/science.171.3966.79
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Articles

Vitamin D: A Cholecalciferol Metabolite Highly Active in Promoting Intestinal Calcium Transport

James F. Myrtle 1 and Anthony W. Norman 1

1 Department of Biochemistry, University of California, Riverside 92502

A major polar metabolite of cholecalciferol (vitamin D3) obtained from chick intestines is over four times as effective as cholecalciferol and over two times as effective as 25-hydroxycholecalciferol in stimulating intestinal calcium transport 24 hours after administration. Following a considerable lag, cholecalciferol and its 25-hydroxy derivative produce a maximum stimulation of the transport response at 24 to 48 hours. The polar intestinal metabolite greatly shortens this lag, stimulating maximum calcium transport by 9 hours. At 9 hours this metabolite is at least 13 times as active as the parent cholecalciferol and as such is a likely candidate for the biologically active form of cholecalciferol in the intestine.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
1,25-Dihydroxyvitamin D in biological fluids: a simplified and sensitive assay.
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Vitamin D: 3-deoxy-lalpha-hydroxyvitamin D3, biologically active analog of lalpha-dihydroxyvitamin D3.
A. Norman, M. Mitra, W. Okamura, and R. Wing (1975)
Science 188, 1013-1015
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Vitamin D Intoxication in an Anephric Child.
S. J. COUNTS, D. J. BAYLINK, F.-H. SHEN, D. J. SHERRARD, and R. O. HICKMAN (1975)
Ann Intern Med 82, 196-200
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1agr-Hydroxy Derivative of Vitamin D3: A Highly Potent Analog of 1agr,25-Dihydroxyvitamin D3.
M. F. Holick, E J. Semmler, H. K. Schnoes, and H. F. Deluca (1973)
Science 180, 190-191
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1,25-Dihydroxycholecalciferol: Identification of the Proposed Active Form of Vitamin D3 in the Intestine.
A. W. Norman, J. F. Myrtle, R. J. Miogett, H. G. Nowicki, V. Williams, and G. Popjaak (1971)
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