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Science 8 January 1971:
Vol. 171. no. 3966, pp. 75 - 77
DOI: 10.1126/science.171.3966.75
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Articles

Hybrid Cell Line from a Cloned Immunoglobulin-Producing Mouse Myeloma and a Nonproducing Mouse Lymphoma

Behzad Mohit 1 and Kang Fan 1

1 Cell Chemistry Laboratory, Clinical Pathology Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20014

A hybrid cell line was established by cell fusion between a cloned Balbic myeloma that is resistant to 8-azaguanine and produces immunoglobulin (ggrG and free kappa chain) and C57BL/6N lymphoma that is resistant to bromo-deoxyuridine and does not produce immunoglobulins. The hybrid cells contained the membrane antigens of both parents; they synthesized free kappa chain; no synthesis of ggrG (ggr2a) heavy chain was detected.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Colocalization of Fc{{gamma}}RI-Targeted Antigen With Class I MHC: Implications for Antigen Processing.
C. A. Guyre, M. E. Barreda, S. L. Swink, and M. W. Fanger (2001)
J. Immunol. 166, 2469-2478
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Direct and Regulated Interaction of Integrin alpha Ebeta 7 with E-Cadherin.
J. M.G. Higgins, D. A. Mandlebrot, S. K. Shaw, G. J. Russell, E. A. Murphy, Y.-T. Chen, W. J. Nelson, C. M. Parker, and M. B. Brenner (1998)
J. Cell Biol. 140, 197-210
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Regulation of Immunoglobulin Expression in Mouse Myeloma Cells.
D. H. Margulies, W. Cieplinski, B. Dharmgrongartama, M. L. Gefter, S. L. Morrison, T. Kelly, and M. D. Scharff (1977)
Cold Spring Harb Symp Quant Biol 41, 781-791
   Abstract »    PDF »
In Vitro and in Vivo Alterations of Long-Term Murine Plasmacytoma Cultures.
G. D. Sorenson and O. S. Pettengill (1975)
Arch Intern Med 135, 114-118
   Abstract »    PDF »


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