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Science 8 January 1971:
Vol. 171. no. 3966, pp. 64 - 66
DOI: 10.1126/science.171.3966.64
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Articles

Chemically Induced Porphyria: Increased Microsomal Heme Turnover after Treatment with Allylisopropylacetamide

Urs A. Meyer 1 and Harvey S. Marver 1

1 Department of Medicine, University of California, San Francisco 94122

Excessive induction of dgr-aminolevulinic acid synthetase in rats after treatment with porphyria-inducing chemicals, such as allylisopropylacetamide, is accompanied by a decrease in microsomal heme and cytochrome P450 concentrations. Measurement of the radioactive decay after labeling of the heme moiety of submicrosomal particles shows increased breakdown of heme in rats treated with allylisopropylacetamide. The effects of allylisopropylacetamide on heme synthesis and heme turnover may be interrelated

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Science. ISSN 0036-8075 (print), 1095-9203 (online)