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Science 27 November 1970:
Vol. 170. no. 3961, pp. 990 - 992
DOI: 10.1126/science.170.3961.990
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Articles

Starvation in Human Pregnancy: Hypoglycemia, Hypoinsulinemia, and Hyperketonemia

Philip Felig 1 and Vincent Lynch 1

1 Departments of Internal Medicine and Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06510

In women fasted during the second trimester of pregnancy, concentrations of glucose and insulin in the plasma fell to a greater extent and ketone acid concentrations in the blood rose more rapidly than in nonpregnant controls. Nitrogen excretion in the urine, particularly ammonia, was increased in the pregnant group. Continuous glucose utilization by the conceptus may exaggerate and accelerate the metabolic consequences of starvation.


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