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Science 27 November 1970:
Vol. 170. no. 3961, pp. 986 - 988
DOI: 10.1126/science.170.3961.986
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Articles

Vascular Lesions: Possible Pathogenetic Basis of the Generalized Shwartzman Reaction

Evelyn Gaynor 1, Claude Bouvier 1, and Theodore H. Spaet 1

1 Hematology Department, Montefiore Hospital and Medical Center, Bronx, New York 10467

Evidence of vascular injury was found in rabbits after a single small dose of endotoxin from Escherichia coli. Eighty percent of the treated animals developed circulating endothelial cells, leukopenia, and thrombocytopenia, and 50 percent had aortic endothelial lesions as determined by electron microscopy. Prior anticoagulation with heparin did not prevent this response. No control animals showed these abnormalities.


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