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Science 30 October 1970:
Vol. 170. no. 3957, pp. 553 - 555
DOI: 10.1126/science.170.3957.553
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Articles

Transfer of Bilirubin Uridine Diphosphate-Glucuronyltransferase to Enzyme-Deficient Rats

Hans E. Rugstad 1, Stephen H. Robinson 1, Claudine Yannoni 1, and Armen H. Tashjian Jr. 1

1 Department of Medicine, Beth Israel Hospital and Harvard Medical School, and Department of Pharmacology, Harvard Medical School, and School of Dental Medicine, Boston, Massachusetts 02215

Cells from a clonal strain (MH1C1) of rat hepatoma were transplanted subcutaneously into two homozygous Gunn rats, which are jaundiced because the enzyme bilirubin uridine diphosphate-glucuronyltransferase is absent from the liver. Because of the enzyme activity present in the transplanted cells, the recipient rats developed the capacity to conjugate bilirubin and reverted in large part to a normal pattern of bilirubin excretion.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Hepatocellular transplantation for metabolic deficiencies: decrease of plasms bilirubin in Gunn rats.
A. Matas, D. Sutherland, M. Steffes, S. Mauer, A Sowe, R. Simmons, and J. Najarian (1976)
Science 192, 892-894
   Abstract »    PDF »
Induction of an Enzyme in Genetically Deficient Rats after Grafting of Normal Liver.
A. B. Mukherjee and J. Krasner (1973)
Science 182, 68-70
   Abstract »    PDF »
Correction of Abnormal Cerebroside Sulfate Metabolism in Cultured Metachromatic Leukodystrophy Fibroblasts.
M. T. Porter, A. L. Fluharty, and H. Kihara (1971)
Science 172, 1263-1265
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)