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Science 23 October 1970:
Vol. 170. no. 3956, pp. 462 - 464
DOI: 10.1126/science.170.3956.462
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Articles

Radioresistance of Cooperative Function of Carrier-Specific Lymphocytes in Antihapten Antibody Responses

David H. Katz 1, William E. Paul 1, Edmond A. Goidl 1, and Baruj Benacerraf 1

1 National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

Transfer of lymphoid cells from strain-2 guinea pigs immunized to bovine gamma globulin into syngeneic recipients immunized with dinitrophenyl ovalbumin markedly enhances the secondary antidinitrophenyl response of the recipient to challenge with dinitrophenyl-bovine gamma globulin. This function of the carrier bovine gamma globulin-specific cells is resistant to irradiation with up to 5000 rads, although the capacity of the irradiated cell population to transfer immunologic memory for bovine gamma globulins or to be stimulated by antigen to synthesize DNA in vitro is abolished by this treatment.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Protective long-term antibody memory by antigen-driven and T help-dependent differentiation of long-lived memory B cells to short-lived plasma cells independent of secondary lymphoid organs.
A. F. Ochsenbein, D. D. Pinschewer, S. Sierro, E. Horvath, H. Hengartner, and R. M. Zinkernagel (2000)
PNAS 97, 13263-13268
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Science. ISSN 0036-8075 (print), 1095-9203 (online)