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Science 16 October 1970:
Vol. 170. no. 3955, pp. 341 - 342
DOI: 10.1126/science.170.3955.341
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Articles

Acetylcholine Concentrations in Rat Brain: Diurnal Oscillation

I. Hanin 1, R. Massarelli 1, and E. Costa 1

1 National Institute of Mental Health, Saint Elizabeths Hospital, William A. White Building, Washington, D.C. 20032

A diurnal oscillation of acetylcholine concentrations in rat brain has been demonstrated by gas chromatography. Peak concentrations occur at 2 hours of light, and a trough is seen at 6 hours of darkness. This pattern is observed only in grouped rats, and emerges after at least 18 days of prior conditioning in an environment with controlled light, humidity, and temperature.


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