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Science 16 October 1970:
Vol. 170. no. 3955, pp. 336 - 338
DOI: 10.1126/science.170.3955.336
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Articles

Estrogenic Induction of Ornithine Decarboxylase in vivo and in vitro

Stanley Cohen 1, Bert W. O'Malley 1, and Milos Stastny 1

1 Departments of Biochemistry, Obstetrics and Gynecology, and Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37203

Injection of estrogens (17beta-estradiol or diethylstilbestrol) into immature chicks results in a marked (30- to 50-fold) increase in the ornithine decarboxylase activity of oviductal homogenates within a 4-hour period. Similar stimulations were obtained when estrogen was injected into hypophysectomized or castrated rats and the uterus was examined for decarboxylase activity. An elevation of decarboxylase activity was obtained in vitro when oviducts from immature chicks were incubated in the presence of estrogen. These data indicate a direct action of estrogen on oviduct tissue to promote a rapid increase in the activity of a specific enzyme and represent the first example of a completely in vitro enzyme response to estrogen.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Ornithine Decarboxylase Stimulation in Rat Ovary by Luteinizing Hormone.
Y. Kobayashi, J. Kupelian, and D. V. Maudsley (1971)
Science 172, 379-380
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Science. ISSN 0036-8075 (print), 1095-9203 (online)