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Science 16 October 1970:
Vol. 170. no. 3955, pp. 326 - 327
DOI: 10.1126/science.170.3955.326
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Articles

Demonstration of Biological Activity of a Murine Leukemia Virus of New Zealand Black Mice

Jay A. Levy 1 and Theodore Pincus 2

1 National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
2 National Institute of Allergy and Infectious Diseases, National Institutes of Health

Although New Zealand Black mouse embryo and adult tissues show evidence of murine leukemia viral particles and antigens, efforts to demonstrate biological activity of a murine leukemia virus by standard methods have proved negative. Cocultivation of tissues of these mice with non-virus-yielding hamster cells transformed by Moloney sarcoma virus, however, has resulted in the rescue of a pseudotype sarcoma virus, presumably carrying the New Zealand Black mouse leukemia virus coat. This virus has an unusual host restriction, producing foci of cell alteration only in rat cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Qualitative and Quantitative Studies of AKR-type Murine Leukemia Virus Sequences in Mouse DNA.
S. K. Chattopadhyay, D. R. Lowy, N. M. Teich, A. S. Levine, and W. P. Rowe (1974)
Cold Spring Harb Symp Quant Biol 39, 1085-1101
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Differential Cellular Regulation of Three Distinct Classes of Type C RNA Viruses Endogenous to Mouse Cells.
S. A. Aaronson and J. R. Stephenson (1974)
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Xenotropic Viruses: Murine Leukemia Viruses Associated with NIH Swiss, NZB, and Other Mouse Strains.
J. A. Levy (1973)
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Science. ISSN 0036-8075 (print), 1095-9203 (online)