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Science 9 October 1970:
Vol. 170. no. 3954, pp. 188 - 190
DOI: 10.1126/science.170.3954.188
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Articles

Adenosine 3',5'-Monophosphate in Rat Pineal Gland: Increase Induced by Light

Manuchair S. Ebadi 1, Benjamin Weiss 1, and Erminio Costa 1

1 Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032

Rats were maintained in alternating periods of 12 hours of light and 12 hours of darkness. The concentration of adenosine 3',5'-monophosphate in pineal gland was six times higher at the end of the light period than at the end of the period of darkness. This effect of light was abolished in blinded animals.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)