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Science 9 October 1970:
Vol. 170. no. 3954, pp. 169 - 171
DOI: 10.1126/science.170.3954.169
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Articles

Dimethylbenzanthracene Tumorigenesis and Aryl Hydrocarbon Hydroxylase in Mouse Skin: Inhibition by 7,8-Benzoflavone

Harry V. Gelboin 1, Friedrich Wiebel 1, and Leila Diamond 2

1 Chemistry Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
2 Wistar Institute, Philadelphia, Pennsylvania 19104

Mouse skin contains aryl hydrocarbon hydroxylase which is highly inducible. The enzyme system is inhibited when 7,8-benzoflavone is added to homogenates of skin epidermis. 7,8-Benzoflavone also inhibits mouse skin tumorigenesis caused by repeated treatment with 9,10-dimethylbenzanthracene or by a single treatment with this chemical followed by weekly treatment with croton oil. These findings suggest that this enzyme system may be responsible for the activation of 9,10-dimethylbenzanthracene to its carcinogenic form.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)