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Science 2 October 1970:
Vol. 170. no. 3953, pp. 89 - 90
DOI: 10.1126/science.170.3953.89
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Articles

Biochemically Marked Lymphocytoid Lines: Establishment of Lesch-Nyhan Cells

Kyoo W. Choi 1 and Arthur D. Bloom 1

1 Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48104

Two lymphocytoid cell lines have been established from a patient with the Lesch-Nyhan syndrome. The cells are deficient in hypoxanthine-guanine phosphoribosyltransferase, as demonstrated by their failure to incorporate [H3]hypoxanthine and by their inability to grow in medium in which they were nutritionally dependent upon exogenous hypoxanthine. This represents the first establishment of presumptively permanent human lymphocytoid cell lines that are deficient in a specific enzyme.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)