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Science 2 October 1970:
Vol. 170. no. 3953, pp. 85 - 87
DOI: 10.1126/science.170.3953.85
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Articles

Heritable Fragile Site on Chromosome 16: Probable Localization of Haptoglobin Locus in Man

R. Ellen Magenis 1, Frederick Hecht 1, and Everett W. Lovrien 1

1 Division of Medical Genetics, Department of Pediatrics, and Genetics Clinic, Crippled Children's Division, University of Oregon Medical School, Portland 97201

We have found recurrent chromosome breaks at a site (the "fragile site") on the long arm of chromosome 16. This site segregates in simple Mendelian dominant fashion in a large family. The distal portion of the chromosome sometimes shows selective endoreduplication. Preliminary linkage results reveal only 3 recombinants in 33 opportunities for recombination between the fragile site and the alpha locus of haptoglobin, an indication that the agr-Hp gene is located near this region on chromosome 16.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Gene Map of Homo sapiens: Status and Prospectus.
V.A. McKusick (1986)
Cold Spring Harb Symp Quant Biol 51, 15-27
   Abstract »    PDF »
Genetic length of a human chromosomal segment measured by recombination between two fragile sites.
G. Sutherland, E Baker, and J. Mulley (1982)
Science 217, 373-374
   Abstract »    PDF »
The status of the gene map of the human chromosomes.
V. McKusick and F. Ruddle (1977)
Science 196, 390-405
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)