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Science 2 October 1970:
Vol. 170. no. 3953, pp. 78 - 80
DOI: 10.1126/science.170.3953.78
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Articles

Reduced Nicotinamide-adenine Dinucleotide Phosphate Oxidase: Activity Enhanced by Ethanol Consumption

Charles S. Lieber 1 and Leonore M. DeCarli 1

1 Department of Medicine, Mt. Sinai School of Medicine of the City University of New York and Section of Liver Disease and Nutrition, Veterans Administration Hospital, Bronx, New York 10468

Prolonged consumption of ethanol enhances the activities of the hepatic microsomal ethanol oxidizing system and of reduced nicotinamide-adenine dinucleotide phosphate oxidase, but not of catalase. The oxidase-catalase system is not part of the microsomal ethanol oxidizing system since catalase inhibitors dissociate ethanol oxidation by the two pathways. Enhanced reduced nicotinamide-adenine dinucleotide phosphate oxidase activity may contribute to liver injury, possibly by favoring lipoperoxidation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Regulation of CYP2E1 by Ethanol and Palmitic Acid and CYP4A11 by Clofibrate in Primary Cultures of Human Hepatocytes.
J. L. Raucy, J. Lasker, K. Ozaki, and V. Zoleta (2004)
Toxicol. Sci. 79, 233-241
   Abstract »    Full Text »    PDF »
Alcoholism, Alcohol, and Drugs.
E. Rubin and C. S. Lieber (1971)
Science 172, 1097-1102
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