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Science 2 October 1970:
Vol. 170. no. 3953, pp. 76 - 77
DOI: 10.1126/science.170.3953.76
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Articles

L-Dopa-Induced Release of Cerebral Monoamines

K. Y. Ng 1, T. N. Chase 1, R. W. Colburn 1, and I. J. Kopin 1

1 Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014

L-Dopa markedly increased the efflux of tritiated dopamine and tritiated serotonin from rat brain slices. This action appeared contingent on the decarboxylation of L-dopa to dopamine, since it could be blocked by an inhibitor of L-amino acid decarboxylase. Selective destruction of catecholamine-containing nerve terminals by 6-hydroxydopamine significantly decreased the uptake and release of tritiated dopamine but not that of tritiated serotonin. These observations support the hypothesis that a portion of exogenously administered L-dopa may enter central serotonin terminals and undergo decarboxylation to the amine with resultant displacement of the endogenous indoleamine from vesicular stores.


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