Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 2 October 1970:
Vol. 170. no. 3953, pp. 74 - 75
DOI: 10.1126/science.170.3953.74
Prev | Table of Contents | Next

Articles

Genetically Controlled Total Deficiency of the Fourth Component of Complement in the Guinea Pig

Leonard Ellman 1, Ira Green 1, and Michael Frank 2

1 Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014
2 Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases

Guinea pigs with a total deficiency of the fourth component of complement (C4) have been discovered. There was no evidence for the presence of a C4 inhibitor in the serum of these animals. Mating studies indicate that C4 deficiency is transmitted as a simple autosomal recessive trait. A colony of these animals is being established at the National Institutes of Health. They will provide an opportunity to more precisely define the role of complement in immune phenomena and the defense against disease.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Treponema pallidum subsp. pertenue Displays Pathogenic Properties Different from Those of T. pallidum subsp. pallidum.
K. Wicher, V. Wicher, F. Abbruscato, and R. E. Baughn (2000)
Infect. Immun. 68, 3219-3225
   Abstract »    Full Text »    PDF »
IgG and Complement-Mediated Tissue Damage in the Absence of C2: Evidence of a Functionally Active C2-Bypass Pathway in a Guinea Pig Model.
E. Wagner, J. L. Platt, D. N. Howell, H. C. Marsh Jr., and M. M. Frank (1999)
J. Immunol. 163, 3549-3558
   Abstract »    Full Text »    PDF »
Genetically determined deficiency of the third component of complement in the dog.
J. Winkelstein, L. Cork, D. Griffin, J. Griffin, R. Adams, and D. Price (1981)
Science 212, 1169-1170
   Abstract »    PDF »
Genetic defect in biosynthesis of the precursor form of the fourth component of complement..
R. E. HALL and H. R. COLTEN (1978)
Science 199, 69-70
   Abstract »    PDF »
Biosynthesis of C4 (Fourth Component of Complement) by Hybrids of C4-Deficient Guinea Pig Cells and HeLa Cells.
H. R. Colten and R. Parkman (1972)
Science 176, 1029-1031
   Abstract »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)