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Science 18 September 1970:
Vol. 169. no. 3951, pp. 1217 - 1218
DOI: 10.1126/science.169.3951.1217
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Articles

Polypeptide with Broad Biological Activity: Isolation from Small Intestine

Sami I. Said 1 and Viktor Mutt 2

1 Department of Medicine, Medical College of Virginia, Richmond 23219
2 Department of Chemistry, Karolinska Institute, Stockholm, Sweden

A polypeptide, which has potent and diverse biological action—including systemic vasodilation, hypotension, increased cardiac output, respiratory stimulation, and hyperglycemia—was isolated from the small intestine of the hog. The peptide has 28 amino acid residues and is chemically distinct from the kinins, "substance P," glucagon, and secretin.


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   Abstract »    PDF »
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   Abstract »    PDF »
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D. Y. GRAHAM, C. D. JOHNSON, P. S. BENTLIF, and J. R. KELSEY Jr. (1975)
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   Abstract »    PDF »
Intestinal Secretion: Stimulation by Peptides.
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   Abstract »    PDF »


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