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Science 11 September 1970:
Vol. 169. no. 3950, pp. 1093 - 1095
DOI: 10.1126/science.169.3950.1093
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Articles

Indole Metabolism in the Pineal Gland: A Circadian Rhythm in N-Acetyltransferase

David C. Klein 1 and Joan L. Weller 1

1 Section on Physiological Controls, Laboratory of Biomedical Sciences, National Institute of Child Health and Human Development, Bethesda, Maryland 20014

The activity of N-acetyltransferase in the rat pineal gland is more than 15 times higher at night than during the day. This circadian rhythm persists in complete darkness, or in blinded animals, and is suppressed in constant lighting. The N-acetyltransferase rhythm is 180° out of phase with the serotonin rhythm and is similar to the norepinephrine and melatonin rhythms. Experiments in vitro indicate that norepinephrine, not serotonin, regulates the activity of N-acetyl-transferase through a highly specific receptor.


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