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Science 28 August 1970:
Vol. 169. no. 3948, pp. 883 - 886
DOI: 10.1126/science.169.3948.883
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Articles

Prostaglandin Receptor Site: Evidence for an Essential Role in the Action of Luteinizing Hormone

F. A. Kuehl Jr. 1, J. L. Humes 1, J. Tarnoff 1, V. J. Cirillo 1, and E. A. Ham 1

1 Merck Institute for Therapeutic Research, Rahway, New Jersey 07065

A dose-response relation was established between prostaglandins and formation of adenosine 3',5'-monophosphate in the mouse ovary. The prostaglandin antagonist, 7-oxa-13-prostynoic acid, blocked the stimulatory effect of prostaglandin E1, prostaglandin E2, and luteinizing hormone on adenosine 3',5'-monophosphate formation in a competitive manner. Kinetic studies made it possible to suggest that there is a single luteinizing-hormone-related prostaglandin receptor in mouse ovaries, and that activation of this prostaglandin receptor is an essential requirement in the action of luteinizing hormone to stimulate adenosine 3',5'-monophosphate formation and steroidogenesis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Glucocorticoid Receptor-Mediated Post-Ceramide Inhibition of the Interleukin-1ß-Dependent Induction of Ovarian Prostaglandin Endoperoxide Synthase-2 in Rats.
M. Irahara, M. Ando, J. Sirois, J. Saito, and E. Y. Adashi (1999)
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Rat Ovarian Prostaglandin Endoperoxide Synthase-1 and -2: Periovulatory Expression of Granulosa Cell-Based Interleukin-1-Dependent Enzymes.
M. Ando, S. Kol, E. Kokia, K. Ruutiainen-Altman, J. Sirois, R. M. Rohan, D. W. Payne, and E. Y. Adashi (1998)
Endocrinology 139, 2501-2508
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Prostaglandins, arachidonic acid, and inflammation.
F. Kuehl Jr and R. Egan (1980)
Science 210, 978-984
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Substances That Inhibit the Actions of Prostaglandins.
J. H. Sanner (1974)
Arch Intern Med 133, 133-146
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Thyrotropin and Cyclic Nucleotide Effects on Prostaglandin Levels in Isolated Thyroid Cells.
G. Burke, L.-L. Chang, and M. Szabo (1973)
Science 180, 872-875
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