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Science 21 August 1970:
Vol. 169. no. 3947, pp. 770 - 773
DOI: 10.1126/science.169.3947.770
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Articles

Immunoglobulin M Heavy Chain Disease: Intracellular Origin of the Mu Chain Fragment

Joel Buxbaum 1, Edward C. Franklin 2, and Matthew D. Scharff 3

1 Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461
2 Department of Medicine, Rheumatic Disease Study Group, New York University School of Medicine, New York
3 Departments of Cell Biology and Medicine, Albert Einstein College of Medicine

Cells obtained from a patient with mu heavy chain disease synthesize a mu heavy chain fragment with a molecular weight of 55,000. The fragment is detected intracellularly after short labeling times and then is assembled inside the cell and secreted as a disulfide-linked polymer.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
{micro}-Chain Disease.
E. C. Franklin (1975)
Arch Intern Med 135, 71-72
   Abstract »    PDF »
Mu-Chain Disease.
S. L. LEE, F. ROSNER, W. RUBERMAN, and S. GLASBERG (1971)
Ann Intern Med 75, 407-414
   Abstract »    PDF »
IgM Heavy Chain Fragments in Waldenstrom's Macroglobulinemia.
N. Bhoopalam, B. M. Lee, V. J. Yakulis, and P. Heller (1971)
Arch Intern Med 128, 437-440
   Abstract »    PDF »


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