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Science 14 August 1970:
Vol. 169. no. 3946, pp. 686 - 688
DOI: 10.1126/science.169.3946.686
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Articles

Fitness of an Escherichia coli Mutator Gene

Thomas C. Gibson 1, Mary L. Scheppe 1, and Edward C. Cox 1

1 Departments of Biology and Biochemical Sciences, Princeton University, Princeton, New Jersey

Competition experiments between Escherichia coli mutT1 and mut+ populations show that the mutator gene confers selective advantage on the strain that carries it. The observed increase in fitness varies, with an average increase in mutator growth rate of 1.4 percent when mutator and wild-type strains are grown together in chemostats.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Molecular analysis of mutS expression and mutation in natural isolates of pathogenic Escherichia coli.
B. Li, H.-C. T. Tsui, J. E. LeClerc, M. Dey, M. E. Winkler, and T. A. Cebula (2003)
Microbiology 149, 1323-1331
   Abstract »    Full Text »    PDF »
The Consequences of Growth of a Mutator Strain of Escherichia coli as Measured by Loss of Function Among Multiple Gene Targets and Loss of Fitness.
P. Funchain, A. Yeung, J. L. Stewart, R. Lin, M. M. Slupska, and J. H. Miller (2000)
Genetics 154, 959-970
   Abstract »    Full Text »
Direct Selection for Mutators in Escherichia coli.
J. H. Miller, A. Suthar, J. Tai, A. Yeung, C. Truong, and J. L. Stewart (1999)
J. Bacteriol. 181, 1576-1584
   Abstract »    Full Text »
Evolution of DNA Base Compositions in Microorganisms.
A. L. Bak, J. F. Atkins, S. A. Meyer, C. E. Singer, and B. N. Ames (1972)
Science 175, 1391-1393
   PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)