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Science 7 August 1970:
Vol. 169. no. 3945, pp. 593 - 595
DOI: 10.1126/science.169.3945.593
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Articles

Serum Hepatitis Antigen (SH): Rapid Detection by High Voltage Immunoelectroosmophoresis

Alfred M. Prince 1 and Kathleen Burke 1

1 Laboratory of Virology, New York Blood Center and Department of Pathology, New York Hospital-Cornell Medical Center, New York

An immunoelectroosmophoretic technique for rapid detection of the antigen (SH) associated with the serum hepatitis virus has been devised. The technique maintains the specificity characteristic of the Ouchterlony gel-diffusion method, yet detects in 1 to 2 hours one-tenth the amount of antigen required for gel diffusion. The test has immediate application to blood-banking practice since it permits the screening of such labile products as platelets and fresh whole blood, and the detection of antigen in additional serums negative by the Ouchterlony technique.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Levamisole Treatment in Acute Hepatitis: A Controlled Study.
S. Ozsoylu, C. Sargin, and N. Kocak (1981)
Clinical Pediatrics 20, 497-500
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Antibody to Hepatitis A Antigen in Institutionalized Mentally Retarded Patients.
W. Szmuness, R. H. Purcell, J. L. Dienstag, and C. E. Stevens (1977)
JAMA 237, 1702-1705
   Abstract »    PDF »
The Liver and the Antigens of Hepatitis B.
G. L. GITNICK, L. S. GOLDBERG, R. KORETZ, and J. H. WALSH (1976)
Ann Intern Med 85, 488-496
   Abstract »    PDF »
Viral Hepatitis: An Occupational Hazard to Surgeons.
J. L. Rosenberg, D. P. Jones, L. R. Lipitz, and J. B. Kirsner (1973)
JAMA 223, 395-400
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Epidemic Hepatitis-Associated Antigen (Milan Antigen) Study on Normal Population and Sporadic Acute Viral Hepatitis.
S. D. Prete, D. Constantino, M. Doglia, M. P. Fabiani, R. Borin, and A. Jacini (1972)
Arch Pediatr Adolesc Med 123, 326-329
   Abstract »    PDF »
Australia Antigen and Polyarteritis Nodosa.
C. G. Trepo, J. Thivolet, and A. M. Prince (1972)
Arch Pediatr Adolesc Med 123, 390-392
   Abstract »    PDF »
Detection of HAA in the Serum of Patients With Primary Carcinoma of the Liver.
R. Masseyeff, A. M. Prince, L. Leblanc, and W. Szmuness (1972)
Arch Pediatr Adolesc Med 123, 412-413
   Abstract »    PDF »
Immune Response in Patients Who Received Blood Containing Serum Hepatitis Antigen.
A. M. Prince, B. Brotman, and C. E. Cherubin (1972)
Arch Pediatr Adolesc Med 123, 415-418
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)