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Science 31 July 1970:
Vol. 169. no. 3944, pp. 493 - 495
DOI: 10.1126/science.169.3944.493
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Articles

Immunoassay of Plasma Low-Density Lipoproteins

Robert S. Lees 1

1 Clinical Research Center and Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge 02139

An immunoassay was developed for determining the concentration of the protein moiety of the low-density lipoproteins of human plasma. The concentration of this protein in the plasma was variable; it was higher than normal on the average in patients with familial hyperbetalipoproteinemia (type II) and endogenous hyperlipemia (type IV) and lower than normal in patients with fat-induced (type I) and mixed (type V) hyperlipemia. Patients with endogenous hyperlipemia were separable by the immunoassay into those with normal and those with supernormal low-density lipoprotein protein concentration.


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