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Science 31 July 1970:
Vol. 169. no. 3944, pp. 492 - 493
DOI: 10.1126/science.169.3944.492
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Articles

Quinacrine: Mechanisms of Antimalarial Action

Knox Van Dyke 1, Christian Lantz 1, and Christopher Szustkiewicz 1

1 Department of Pharmacology, West Virginia University Medical Center, Morgantown 26506

Two new interesting modes of action of quinacrine have been discovered. The first concerns a dose-related inhibition of uptake of [8-3H] adenosine into host cells of parasitized blood. Second, the drug inhibits the incorporation of tritiated adenosine triphosphate primarily into RNA but also into DNA of the erythrocyte-free malarial parasite Plasmodium berghei.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)