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Science 24 July 1970:
Vol. 169. no. 3943, pp. 388 - 390
DOI: 10.1126/science.169.3943.388
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Articles

Allopurinol: Alteration in Pyrimidine Metabolism in Man

William N. Kelley 1 and Thomas D. Beardmore 1

1 Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina 27706

In addition to its well-established inhibitory effect on uric acid synthesis, allopurinol appears to alter substantially pyrimidine metabolism, as evidenced by a striking increase in the urinary excretion of orotidine and orotic acid. Allopurinol ribonucleotide and xanthosine 5'-monophosphate are potent inhibitors of human erythrocyte orotidylic decarboxylase and provide a possible mechanism for this effect.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)