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Science 24 July 1970:
Vol. 169. no. 3943, pp. 375 - 377
DOI: 10.1126/science.169.3943.375
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Articles

Hemoglobin Interaction: Modification of Solid Phase Composition in the Sickling Phenomenon

John F. Bertles 1, Rosanne Rabinowitz 1, and Johanna Döbler 1

1 Hematology Unit, Medical Service, St. Luke's Hospital Center, and Department of Medicine, Columbia University College of Physicians and Surgeons, New York 10025

Direct analyses of solid phase formed by deoxygenating solutions of sickle-cell hemoglobin (Hb S) in the presence of certain other hemoglobin species show that hemoglobins A and C can participate in the filamentous fine structure characteristic of the sickling phenomenon. In contrast, fetal hemoglobin (Hb F) is nearly completely excluded.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Rational approaches to chemotherapy: antisickling agents.
I. Klotz, D. Haney, and L. King (1981)
Science 213, 724-731
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Gelation of Sickle Cell Hemoglobin: Effects of Hybrid Tetramer Formation in Hemoglobin Mixtures.
K. Moffat (1974)
Science 185, 274-277
   Abstract »    PDF »
Hemoglobin Interaction and Molecular Basis of Sickling.
J. F. Bertles (1974)
Arch Intern Med 133, 538-543
   Abstract »    PDF »
Ultrastructure of the Normal and Hemoglobinopathic Red Blood Cell Membrane: Freeze-Etching and Stereoscan Electron Microscopic Studies.
L. S. Lessin, W. N. Jensen, and P. Klug (1972)
Arch Intern Med 129, 306-319
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)