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Science 24 July 1970:
Vol. 169. no. 3943, pp. 339 - 344
DOI: 10.1126/science.169.3943.339
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Articles

Cyclic Adenosine Monophosphate in Bacteria

In many bacteria the synthesis of inducible enzymes requires this cyclic nucleotide

Ira Pastan 1 and Robert Perlman 2

1 Molecular Biology Section, Endocrinology Branch, National Cancer Institute
2 Diabetes Section, Clinical Endocrinology Branch, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014

Both cyclic AMP and a specific inducer acting in concert are required for the synthesis of many inducible enzymes in E. coli. Little enzyme is made in the absence of either. In contrast to the specific inducers which stimulate the synthesis only of the proteins required for their metabolism, cyclic AMP controls the synthesis of many proteins. Glucose and certain other carbohydrates decrease the differential rate of synthesis of inducible enzymes by lowering cyclic AMP concentrations. In the lac operon, cyclic AMP acts at the promoter site to facilitate initiation of transcription. This action requires another protein, the cyclic AMP receptor protein. The nucleotide stimulates tryptophanase synthesis at a translational level. The action of cyclic AMP in E. coli may serve as a model to understand its action on transcriptional and translational processes in eukaryotes.


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