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Science 17 July 1970:
Vol. 169. no. 3942, pp. 289 - 290
DOI: 10.1126/science.169.3942.289
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Articles

Plasmodium falciparum in Owl Monkeys: Drug Resistance and Chloroquine Binding Capacity

Coy D. Fitch 1

1 Division of Biochemistry, Walter Reed Army Institute of Research, Washington, D.C. 20012

Erythrocytes infected with chloroquine-sensitive Plasmodium falciparum bind chloroquine with an apparent intrinsic association constant of 1.5 x 107 liters per mole. Such high-affinity binding of chloroquine is absent or deficient in uninfected erythrocytes and in erythrocytes infected with chloroquine-resistant Plasmodium falciparum.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Chloroquine Resistance-Conferring Mutations in pfcrt Give Rise to a Chloroquine-Associated H+ Leak from the Malaria Parasite's Digestive Vacuole.
A. M. Lehane and K. Kirk (2008)
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A verapamil-sensitive chloroquine-associated H+ leak from the digestive vacuole in chloroquine-resistant malaria parasites.
A. M. Lehane, R. Hayward, K. J. Saliba, and K. Kirk (2008)
J. Cell Sci. 121, 1624-1632
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Effects of Piperaquine, Chloroquine, and Amodiaquine on Drug Uptake and of These in Combination with Dihydroartemisinin against Drug-Sensitive and -Resistant Plasmodium falciparum Strains.
Q. L. Fivelman, I. S. Adagu, and D. C. Warhurst (2007)
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The pH of the digestive vacuole of Plasmodium falciparum is not associated with chloroquine resistance.
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J. Cell Sci. 119, 1016-1025
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The Malaria Parasite's Chloroquine Resistance Transporter is a Member of the Drug/Metabolite Transporter Superfamily.
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Hydroxychloroquine is much less active than chloroquine against chloroquine-resistant Plasmodium falciparum, in agreement with its physicochemical properties.
D. C. Warhurst, J. C. P. Steele, I. S. Adagu, J. C. Craig, and C. Cullander (2003)
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Alternative Mutations at Position 76 of the Vacuolar Transmembrane Protein PfCRT Are Associated with Chloroquine Resistance and Unique Stereospecific Quinine and Quinidine Responses in Plasmodium falciparum.
R. A. Cooper, M. T. Ferdig, X.-Z. Su, L. M. B. Ursos, J. Mu, T. Nomura, H. Fujioka, D. A. Fidock, P. D. Roepe, and T. E. Wellems (2002)
Mol. Pharmacol. 61, 35-42
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Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America.
R. K. Mehlotra, H. Fujioka, P. D. Roepe, O. Janneh, L. M. B. Ursos, V. Jacobs-Lorena, D. T. McNamara, M. J. Bockarie, J. W. Kazura, D. E. Kyle, et al. (2001)
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A Molecular Marker for Chloroquine-Resistant Falciparum Malaria.
A. Djimde, O. K. Doumbo, J. F. Cortese, K. Kayentao, S. Doumbo, Y. Diourte, A. Dicko, X.-z. Su, T. Nomura, D. A. Fidock, et al. (2001)
N. Engl. J. Med. 344, 257-263
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Cellular Uptake of Chloroquine Is Dependent on Binding to Ferriprotoporphyrin IX and Is Independent of NHE Activity in Plasmodium falciparum.
P. G. Bray, O. Janneh, K. J. Raynes, M. Mungthin, H. Ginsburg, and S. A. Ward (1999)
J. Cell Biol. 145, 363-376
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Access to Hematin: The Basis of Chloroquine Resistance.
P. G. Bray, M. Mungthin, R. G. Ridley, and S. A. Ward (1998)
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In Vitro Antimalarial Activity of a New Organometallic Analog, Ferrocene-Chloroquine.
O. Domarle, G. Blampain, H. Agnaniet, T. Nzadiyabi, J. Lebibi, J. Brocard, L. Maciejewski, C. Biot, A. J. Georges, and P. Millet (1998)
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Differential Stimulation of the Na+/H+ Exchanger Determines Chloroquine Uptake in Plasmodium falciparum.
S. Wunsch, C. P. Sanchez, M. Gekle, L. Grosse-Wortmann, J. Wiesner, and M. Lanzer (1998)
J. Cell Biol. 140, 335-345
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Identification of a Chloroquine Importer in Plasmodium falciparum. DIFFERENCES IN IMPORT KINETICS ARE GENETICALLY LINKED WITH THE CHLOROQUINE-RESISTANT PHENOTYPE.
C. P. Sanchez, S. Wunsch, and M. Lanzer (1997)
J. Biol. Chem. 272, 2652-2658
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Reversal of chloroquine resistance in malaria parasite Plasmodium falciparum by desipramine.
A. Bitonti, A Sjoerdsma, P. McCann, D. Kyle, A. Oduola, R. Rossan, W. Milhous, and D. Davidson Jr (1988)
Science 242, 1301-1303
   Abstract »    PDF »
Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance.
D. Krogstad, I. Gluzman, D. Kyle, A. Oduola, S. Martin, W. Milhous, and P. Schlesinger (1987)
Science 238, 1283-1285
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Reversal of chloroquine resistance in Plasmodium falciparum by verapamil.
S. Martin, A. Oduola, and W. Milhous (1987)
Science 235, 899-901
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