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Science 17 July 1970:
Vol. 169. no. 3942, pp. 282 - 284
DOI: 10.1126/science.169.3942.282
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Articles

Alcohol Oxidation in Rats Inhibited by Pyrazole, Oximes, and Amides

David Lester 1 and Gordon D. Benson 1

1 Center of Alcohol Studies and Department of Medicine, Rutgers Medical School, New Brunswick, New Jersey 08903

Pyrazole, previously reported to inhibit ethanol oxidation in the rat, also effectively blocks the in vivo metabolism of methanol, propanol, isopropanol, n-butanol, and isobutanol. A variety of oximes and amides are also effective inhibitors of ethanol metabolism. These various inhibitors may prove important in the elucidation of several facets of alcohol metabolism and also may have application in the treatment of methanol poisoning and in the reduction of the sequelae of the disulfiram-ethanol reaction syndrome in man.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)