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Science 10 July 1970:
Vol. 169. no. 3941, pp. 206 - 208
DOI: 10.1126/science.169.3941.206
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Articles

Brain Adenosine Triphosphate: Decreased Concentration Precedes Convulsions

Aaron P. Sanders 1, Richard S. Kramer 1, Barnes Woodhall 1, and William D. Currie 1

1 Departments of Radiology, Surgery, and Physiology, Duke University Medical Center, Durham, North Carolina 27706

The concentration of adenosine triphosphate in the brain decreased before the onset of generalized convulsions in unanesthetized rats subjected to acute hypoxia or treated with hydroxylamine or pentylenetetrazole (Metrazol). As the convulsive episode continued, adenosine triphosphate decreased further. Stimulation of adenosine triphosphate production forestalled its disappearance from the brain and delayed the development of seizure activity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Alzheimer II Astrocytosis Following Methionine Sulfoximine.
J. A. Gutierrez and M. D. Norenberg (1975)
Arch Neurol 32, 123-126
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Science. ISSN 0036-8075 (print), 1095-9203 (online)