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Science 10 July 1970:
Vol. 169. no. 3941, pp. 201 - 203
DOI: 10.1126/science.169.3941.201
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Articles

In vivo Conversion of 3H-L-Tryptophan into 3H-Serotonin in Brain Areas of Adrenalectomized Rats

E. C. Azmitia Jr. 1, S. Algeri 2, and E. Costa 2

1 Rockefeller University, New York
2 Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032

Rats were adrenalectomized 10 days before we estimated in vivo the conversion index of 3H-tryptophan into radioactive serotonin in brainstem and telediencephalon. We found that the conversion index in the brainstem of adrenalectomized rats is smaller than in the same area of sham-operated rats. Conversely, the conversion index in the telediencephalon was similar in the two groups of rats. The serotonin concentrations were unchanged by adrenalectomy, which suggests that in brainstem the decrease of tryptophan hydroxylase is reflected by the conversion index estimation and not by measurement of serotonin steady-state concentrations.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)