DNA Polymerase Activities Associated with Smooth Membranes and Ribosomes from Rat Liver and Hepatoma Cytoplasm
Earl F. Baril 1,
Murphy D. Jenkins 1,
Oliver E. Brown 1, and
John Laszlo 1
1 Department of Physiology and Pharmacology and Department of Medicine, Duke University Medical Center and Veterans Administration Hospital, Durham, North Carolina
Deoxyribonucleic acid polymerase activity that prefers denatured DNA primer concentrates with the smooth membranes during sucrose gradient centrifugation of rat liver and hepatoma cytoplasmic extracts. The activity in this fraction is eightfold higher in hepatoma tissue. Deoxyribonucleic acid polymerase activity that prefers native DNA primer concentrates with the free ribosome fraction from both tissues.