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Science 3 July 1970:
Vol. 169. no. 3940, pp. 56 - 59
DOI: 10.1126/science.169.3940.56
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Articles

Macroglobulin Structure: Variable Sequence of Light and Heavy Chains

Heinz Köhler 1, Akira Shimizu 1, Claudine Paul 1, and Frank W. Putnam 1

1 Department of Zoology, Indiana University, Bloomington 47401

The variable regions of the light and heavy chains on the same macroglobulin (immunoglobulin M) molecule are no more related in amino acid sequence than are the variable regions of the light and heavy chains of different immunoglobulin molecules. Subgroups of µ chains are similar in their variable sequence to subgroups of ggr chains.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Immunoglobulin Genes: Arranged in Tandem or in Parallel?.
O. Smithies (1974)
Cold Spring Harb Symp Quant Biol 38, 725-737
   Abstract »    PDF »
Complete Amino Acid Sequence of the Mu Heavy Chain of a Human IgM Immunoglobulin.
F. W. Putnam, G. Florent, C. Paul, T. Shinoda, and A. Shimizu (1973)
Science 182, 287-291
   Abstract »    PDF »
Variation and Homology in the Mu and Gamma Heavy Chains of Human Immunoglobulins.
A. Shimizu, C. Paul, H. Kohler, T. Shinoda, and F. W. Putnam (1971)
Science 173, 629-633
   Abstract »    PDF »
Structure of the Hinge Region of the Mu Heavy Chain of Human IgM Immunoglobulins.
C. Paul, A. Shimizu, H. Kohler, and F. W. Putnam (1971)
Science 172, 69-72
   Abstract »    PDF »


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