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Science 26 June 1970:
Vol. 168. no. 3939, pp. 1599 - 1601
DOI: 10.1126/science.168.3939.1599
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Articles

Impairment of Shock Avoidance Learning after Long-Term Alcohol Ingestion in Mice

Gerhard Freund 1

1 Veterans Administration Hospital and Department of Medicine, University of Florida, Gainesville 32601

Chronic alcohol consumption impaired the learning of a two-way shuttle box avoidance task in mice 10 to 14 days after the discontinuation of ethanol in the diet. Control groups received laboratory chow ad libitum or were pair-fed with the alcohol-consuming mice by diets containing isocaloric amounts of sucrose. The performance of the two control groups was indistinguishable from each other, and only the ethanol-consuming mice performed poorly. It was therefore concluded that alcohol consumption per se and not a nutritional deficiency was responsible for the impairment of learning.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Health Hazards Associated With Alcohol Consumption.
M. J. Eckardt, T. C. Harford, C. T. Kaelber, E. S. Parker, L. S. Rosenthal, R. S. Ryback, G. C. Salmoiraghi, E. Vanderveen, and K. R. Warren (1981)
JAMA 246, 648-666
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Morphological alterations in hippocampus after long-term alcohol consumption in mice.
J. Riley and D. Walker (1978)
Science 201, 646-648
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Impairment of Timing Behavior after Prolonged Alcohol Consumption in Rats.
D. W. Walker and G. Freund (1973)
Science 182, 597-599
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