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BioProduction 2008

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Science 26 June 1970:
Vol. 168. no. 3939, pp. 1598 - 1599
DOI: 10.1126/science.168.3939.1598
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Articles

Pyrazole and Induction of Fatty Liver by a Sigle Dose of Ethanol

Gonzalo Orchard Bustos 1, Harold Kalant 1, Jatinder M. Khanna 1, and Juliet Loth 1

1 Department of Pharmacology, University of Toronto, Toronto 5, Ontario, Canada

Pyrazole (4 millimoles per kilogram or 272 milligrams per kilogram of body weight), given to fasted rats 10 minutes before gavage with ethanol (4 grams per kilogram), completely prevented both the disappearance of ethanol from the blood over a 16-hour period and the ethanol-induced reduction in the ratio of oxidized to reduced hepatic nicotinamide-adenine dinucleotide. However, it did not affect the accumulation of triglycerides in the liver after the administration of ethanol. These results indicate that metabolism of ethanol is not required for production of fatty liver by a single, large dose of ethanol.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Synergy of Ethanol and a Natural Soporific--Gamma Hydroxybutyrate.
E. R. McCabe, E. C. Layne, D. F. Sayler, N. Slusher, and S. P. Bessman (1971)
Science 171, 404-406
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)