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Science 26 June 1970:
Vol. 168. no. 3939, pp. 1595 - 1597
DOI: 10.1126/science.168.3939.1595
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Articles

Mouse Lysozyme Production by a Monocytoma: Isolation and Comparison with Other Lysozymes

Roy J. Riblet 1 and Leonard A. Herzenberg 1

1 Department of Genetics, Stanford University Medical School, Stanford, California 94305

A transplantable mouse tumor, GPC-11, produces large amounts of lysozyme. The tumor is a reticulum cell sarcoma, type A, and is a neoplasm of monocytes. The lysozyme was purified from mouse urine in quantities sufficient for structural analysis. Comparison of mouse lysozyme with lysozymes from; chicken egg white and patients with monocytic leukemia reveals similarities in size and electrophoretic mobility and, with human lysozyme, in functional properties; but considerable differences are found in antigenic characteristics and amino acid composition.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mouse Lysozyme-M Knockout Mice Reveal How the Self-Determinant Hierarchy Shapes the T Cell Repertoire against This Circulating Self Antigen in Wild-Type Mice.
P. Sinha, H. H. Chi, H. R. Kim, B. E. Clausen, B. Pederson, E. E. Sercarz, I. Forster, and K. D. Moudgil (2004)
J. Immunol. 173, 1763-1771
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Mutant Mouse Lysozyme Carrying a Minimal T Cell Epitope of Hen Egg Lysozyme Evokes High Autoantibody Response.
Y. Tsujihata, T. So, Y. Chijiiwa, Y. Hashimoto, M. Hirata, T. Ueda, and T. Imoto (2000)
J. Immunol. 165, 3606-3611
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The Self-Directed T Cell Repertoire Against Mouse Lysozyme Reflects the Influence of the Hierarchy of Its Own Determinants and Can Be Engaged by a Foreign Lysozyme.
K. D. Moudgil, S. Southwood, A. Ametani, K. Kim, A. Sette, and E. E. Sercarz (1999)
J. Immunol. 163, 4232-4237
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)