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Science 19 June 1970:
Vol. 168. no. 3938, pp. 1477 - 1478
DOI: 10.1126/science.168.3938.1477
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Articles

Defect in DNA Synthesis in Skin of Patients with Xeroderma Pigmentosum Demonstrated in vivo

John H. Epstein 1, Kimie Fukuyama 1, William B. Reed 1, and William L. Epstein 1

1 Department of Dermatology, University of California School of Medicine, San Francisco 94122

Exposure of normal human skin in vivo to ultraviolet irradiation at wavelengths shorter than 320 nanometers stimtulated an unscheduled DNA synthesis in all of the cell layers of the epidermis and in the upper dermnial fibrocytes. The skin of patients with xeroderma pigmentosum did not show this response. correlation of these findings with previous tissue culture studies suggests that the defect in repair of the damaged DNA in xeroderma cells occurs in vivo as well as in vitro.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Reduced DNA Repair in Cultured Melanocytes and Nevus Cells From a Patient With Xeroderma Pigmentosum.
K. H. Kraemer, M. Herlyn, S. H. Yuspa, W. H. Clark Jr, G. K. Townsend, G. R. Neises, and V. J. Hearing (1989)
Arch Dermatol 125, 263-268
   Abstract »    PDF »
Xeroderma Pigmentosum: Cutaneous, Ocular, and Neurologic Abnormalities in 830 Published Cases.
K. H. Kraemer, M. M. Lee, and J. Scotto (1987)
Arch Dermatol 123, 241-250
   Abstract »    PDF »
DeSanctis-Cacchione Syndrome: A Case Report With Autopsy Findings.
W. B. Reed, G. I. Sugarman, and R. A. Mathis (1977)
Arch Dermatol 113, 1561-1563
   Abstract »    PDF »
Reflections and Perspectives Concerning Cutaneous Photobiology.
L. C. Harber (1976)
Arch Dermatol 112, 1668-1670
   Abstract »    PDF »
Repair of DNA in Xeroderma Pigmentosum Conjunctiva.
D. A. Newsome, K. H. Kraemer, and J. H. Robbins (1975)
Arch Ophthalmol 93, 660-662
   Abstract »    PDF »
Ocular Manifestations of Xeroderma Pigmentosum in a Black Family.
R. A. Bellows, M. Lahav, F. J. Lepreau, and D. M. Albert (1974)
Arch Ophthalmol 92, 113-117
   Abstract »    PDF »
Xeroderma Pigmentosum: An Inherited Disease with Sun Sensitivity, Multiple Cutaneous Neoplasms, and Abnormal DNA Repair.
J. H. ROBBINS, K. H. KRAEMER, M. A. LUTZNER, B. W. FESTOFF, and H. G. COON (1974)
Ann Intern Med 80, 221-248
   Abstract »    PDF »
Dermatome Shaving in the Treatment of Xeroderma Pigmentosum.
E. H. Epstein Jr., P. G. Burk, I. K. Cohen, and P. Deckers (1972)
Arch Dermatol 105, 589-590
   Abstract »    PDF »


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