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Science 19 June 1970:
Vol. 168. no. 3938, pp. 1457 - 1458
DOI: 10.1126/science.168.3938.1457
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Articles

Diphenylhydantoin and Diazepam: Molecular Structure Similarities and Steric Basis of Anticonvulsant Activity

Arthur Camerman 1 and Norman Camerman 2

1 Department of Biological Structure, University of Washington, Seattle 98105
2 Department of Biochemistry, University of Toronto, Toronto 181, Canada

Diphenylhydantoin and diazepam are two useful antiepileptic drugs. Though not obviously related chemically, their molecular conformations exhibit marked similarities. These similarities indicate a steric basis for their anticonvulsant activity and lead to conclusions about the receptor sites for this type of pharmaceutical.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Micromolar affinity benzodiazepine receptors: identification and characterization in central nervous system.
A. Bowling and R. DeLorenzo (1982)
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Benzodiazepine inhibition of the calcium-calmodulin protein kinase system in brain membrane.
R. DeLorenzo, S Burdette, and J Holderness (1981)
Science 213, 546-549
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Similarity of Diazepam to Diphenylhydantoin.
G. C. Schussler (1971)
JAMA 218, 1832
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Ventricular Arrhythmias And Diazepam.
M. A. Nevins (1971)
JAMA 215, 643
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