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Science 12 June 1970:
Vol. 168. no. 3937, pp. 1370 - 1372
DOI: 10.1126/science.168.3937.1370
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Articles

Intracranial Self-Stimulation and Wakefulness: Effect of Manipulating Ambient Brain Catecholamines

Susan Kushner Roll 1

1 Department of Psychology, University of California, San Diego

Rats were given disulfiram, an inhibitor of norepinephrine biosynthesis, to see if norepinephrine is a transmitter for motivation in electrical stimulation of the brain. Animals given the drug paused in bar pressing, appearing asleep or sedated; if replaced on the bar, they always resumed pressing at normal rates. The decrease in bar pressing may result from a direct or indirect effect of the drug on wakefulness rather than on reward.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Increased lever pressing for amphetamine after pimozide in rats: implications for a dopamine theory of reward.
R. Yokel and R. Wise (1975)
Science 187, 547-549
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6-Hydroxydopamine, Noradrenergic Reward, and Schizophrenia.
S. M. Antelman, A. S. Lippa, A. E. Fisher, M. B. Bowers Jr., M. H. Van Woert, J. S. Strauss, W. T. Carpenter Jr., L. Stein, and C. D. Wise (1972)
Science 175, 919-923
   PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)