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Science 12 June 1970:
Vol. 168. no. 3937, pp. 1347 - 1348
DOI: 10.1126/science.168.3937.1347
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Articles

Morphine: Radioimmunoassay

Sydney Spector 1 and Charles W. Parker 2

1 Roche Institute of Molecular Biology, Nutley, New Jersey 07110
2 Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110

The development of a radioimmunoassay for morphine is described.The hapten morphine is made antigenic by coupling it to a protein at the phenolic group of the molecule. Extremely low concentrations of morphine (0.5 nanogram) can be measured by this assay procedure.


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