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Science 5 June 1970:
Vol. 168. no. 3936, pp. 1244 - 1246
DOI: 10.1126/science.168.3936.1244
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Articles

Alcohol Aversion in the Rat: Behavioral Assessment of Noxious Drug Effects

Marvin Nachman 1, David Lester 2, and Jacques Le Magnen 3

1 Department of Psychology, University of California, Riverside 92502
2 Center of Alcohol Studies, Rutgers University, New Brunswick, New Jersey
3 Centre National de la Recherche Scientifique, Collège de France, Paris 5e

Injections of p-chlorophenylalanine or n-butyraldoxime given after rats were first given a 10-minute drinking test with saccharin or ethanol solutions produced a learned aversion to these solutions. These findings suggest that the reduced self-selection of alcohol (preference) resulting from the administration of these drugs, reported by others, is not specifically alcohol-related. The technique described offers a sensitive procedure for the assessment of unpleasant effects of drugs.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)