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Science 29 May 1970:
Vol. 168. no. 3935, pp. 1117 - 1118
DOI: 10.1126/science.168.3935.1117
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Articles

Malaria Resistance: Artificial Induction with a Partially Purified Plasmodial Fraction

Lawrence E. D'Antonio 1, Dan T. Spira 1, Rosa Chang Fu 1, Donna M. Dagnillo 1, and Paul H. Silverman 1

1 Department of Zoology, University of Illinois, Urbana 61801

Plasmodium berghei were released from mouse erythrocytes by passage through a French pressure cell. The released organisms were washed and disintegrated; the soluble portion was chromatographed on a Sephadex (G-200) column. The void-volume eluate contained an erythrocyte-free plasmodial fraction which behaved as a vaccine, preventing parasitemia, anemia, and death in mice subsequently challenged with living Plasmodium berghei.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
An effective immunization of experimental monkeys against a human malaria parasite, Plasmodium falciparum.
W. Siddiqui (1977)
Science 197, 388-389
   Abstract »    PDF »
Malaria Resistance: Artificial Induction with a Partially Purified Plasmodial Fraction.
R. T. Cook, M. Aikawa, L. E. D'Antonio, and P. H. Silverman (1971)
Science 171, 1175-1176
   PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)