Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 29 May 1970:
Vol. 168. no. 3935, pp. 1105 - 1108
DOI: 10.1126/science.168.3935.1105
Prev | Table of Contents | Next

Articles

Lymphocytic Responses to Streptococcal Antigens in Glomerulonephritic Patients

J. B. Zabriskie 1, R. Lewshenia 2, G. Möller 2, B. Wehle 3, and R. E. Falk 4

1 Rockefeller University, New York, New York 10021
2 Bakteriologiska Institutionen, Karolinska Institutet, Stockholm, Sweden
3 St. Eric's Hospital, Stockholm, Sweden
4 Department of Surgery, University of Toronto, Toronto 181, Canada

The lymphocytes from patients with progressive glomerulonephritis showed significant inhibition of cell migration in the presence of group A streptococcal particulate antigens. Marked increases in the level of DNA synthesis of these lymphocytes were also observed after contact with these antigens. Lymphocytes from patients with unrelated renal disorders exhibited minimum reactivity to streptococcal antigens.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Streptococcal M protein enhances TGF-{beta} production and increases surface IgA-positive B cells in vitro in IgA nephropathy.
Y. Nishikawa, R. Shibata, Y. Ozono, H. Ichinose, M. Miyazaki, T. Harada, and S. Kohno (2000)
Nephrol. Dial. Transplant. 15, 772-777
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)