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Science 29 May 1970:
Vol. 168. no. 3935, pp. 1095 - 1096
DOI: 10.1126/science.168.3935.1095
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Articles

Cross-Reactions between Streptococcal M Proteins and Human Transplantation Antigens

Arthur A. Hirata 1 and Paul I. Terasaki 2

1 Department of Molecular Biology, Abbott Laboratories, North Chicago, Illinois 60064
2 Department of Surgery, University of California, Los Angeles 90024

Allogeneic antiserums against human lymphocytes were specifically inhibited by M protein from beta hemolytic group A Streptococcus pyogenes, type 1. Analogous M proteins from streptococcus types 3, 4, 5, 6, 12, and 14 had little or no inhibitory activity. The specific inhibition by M protein is not a result of anticomplementary activity or of coating of the lymphocyte surface. Streptococcal polysaccharide and 73 other polysaccharides were inactive. Because all seven HL-A specificities tested were inhibited, it is inferred that M1 protein has a structure common to human histocompatibility antigens.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
HL-A Antigens in Mummified Pre-Columbian Tissues.
P. Stastny (1974)
Science 183, 864-866
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Science. ISSN 0036-8075 (print), 1095-9203 (online)